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You may have heard the phrase “the gut is the second brain.” For people with autoimmune disease, this connection between the digestive system and the brain isn’t just a theory—it’s often a lived experience. Many patients report issues like brain fog, mood swings, or anxiety alongside digestive discomfort, even when the symptoms don’t seem obviously related.

How the gut and brain are connected

The gut and brain are in constant communication through what’s called the gut-brain axis. This is a complex network of nerves, hormones, and immune signals that helps regulate mood, digestion, inflammation, and more. A large portion of the immune system lives in the gut, which means any imbalance in gut health can influence immune responses throughout the body.

What this means for autoimmune conditions

When the gut is inflamed or out of balance—something known as dysbiosis—it can trigger immune system changes that may lead to flares or symptom worsening. It can also affect how you feel emotionally, since certain gut bacteria play a role in producing mood-regulating neurotransmitters like serotonin.

Common signs of gut-brain imbalance

• Frequent bloating, cramping, or gas
• Brain fog or trouble concentrating
• Increased anxiety or low mood
• Food sensitivities that come and go
• Poor sleep or chronic fatigue

Ways to support gut-brain health

• Eat fiber-rich foods to nourish good bacteria
• Include fermented foods like yogurt or sauerkraut
• Stay hydrated and avoid excessive alcohol or sugar
• Manage stress with gentle movement, breathing, or mindfulness
• Talk to your provider before starting probiotics or supplements

Every system is connected

If you’re managing an autoimmune disease, you already know that symptoms rarely stay in one part of the body. The gut-brain connection is one more piece of the puzzle. Supporting your digestion and reducing stress may not just help your stomach—it could help your mind and immune system too.

Your Symptoms Matter

If you’re ready to take the next step toward clarity and relief, the team at AMS Rheumatology in Amarillo is here to walk with you, providing compassionate care, expert guidance, and personalized treatment plans designed to help you regain control, reduce discomfort, and improve your quality of life.